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-synuclein, which is a primary component of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, which is an E3 ubiquitin ligase and leads to endoplasmic reticulum (ER) stress, suggest that dysfunction from the intracellular proteinase methods, for example ubiquitin-proteasome process or lysosomal method, which gets rid of unneeded poison

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